Adenovirus vector-mediated in vivo gene transfer into adult murine retina.

Abstract

PURPOSE To determine whether a reporter gene can be introduced into the adult mammalian retina in vivo through means of a recombinant replication-deficient adenovirus. METHODS A dilution series of purified Ad.CMVlacZ ranging from 10(5) to 10(11) pfu/ml was prepared and microinjected into the subretinal space of adult CD-1 mice. This virus contained the… (More)

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