Adenovirus vector-induced expression of the C-X-C chemokine IP-10 is mediated through capsid-dependent activation of NF-kappaB.

@article{Borgland2000AdenovirusVE,
  title={Adenovirus vector-induced expression of the C-X-C chemokine IP-10 is mediated through capsid-dependent activation of NF-kappaB.},
  author={Stephanie L Borgland and Gloria P. Bowen and Norman C. W. Wong and T. A. Libermann and Daniel A Muruve},
  journal={Journal of virology},
  year={2000},
  volume={74 9},
  pages={3941-7}
}
The use of adenovirus vectors for gene therapy has been limited by well-defined cellular and humoral immune responses. We have previously shown that adenovirus vectors rapidly induce the expression of the C-X-C chemokine, interferon-inducible protein 10 (IP-10), in vivo. Various first-generation, type 5 adenovirus vectors, including adCMVbetagal and UV-psoralen-inactivated adenovirus, equally induced the expression of IP-10 mRNA as early as 3 h following infection in mouse renal epithelial… CONTINUE READING
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Inhibition of endothelial cell activation by adenovirusmediated expression of IkBa, an inhibitor of the transcription factor NFkB

  • C. J. Wrighton, R. Hofer-Warbinek, T. Moll, R. Eytner, F. H. Bach, R. de Martin
  • J. Exp. Med
  • 1996
Highly Influential
8 Excerpts

Rapid induction of multiple chemokines by replication-deficient adenoviral vectors results in acute neutrophil-dependent hepatic toxicity in vivo

  • D. A. Muruve, M. J. Barnes, I. E. Stillman, T. A. Libermann
  • Hum. Gene Ther
  • 1999
Highly Influential
3 Excerpts

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