Adenovirus type 5 substituted with type 11 or 35 fiber structure increases its infectivity to human cells enabling dual gene transfer in CD46-dependent and -independent manners.

@article{Yu2007AdenovirusT5,
  title={Adenovirus type 5 substituted with type 11 or 35 fiber structure increases its infectivity to human cells enabling dual gene transfer in CD46-dependent and -independent manners.},
  author={Ling Yu and Osamu Shimozato and Quanhai Li and Kiyoko Kawamura and Guangyu Ma and Masayoshi Namba and Tomoko Ogawa and Ikuo Kaiho and Masatoshi Tagawa},
  journal={Anticancer research},
  year={2007},
  volume={27 4B},
  pages={2311-6}
}
Infectivity of adenovirus type 5 (Ad5) to cells depends primarily on its fiber-mediated binding to the coxsackievirus and adenovirus receptor (CAR) on target cells. Down-regulated CAR expression, often found in human tumors, hampered Ad5-mediated gene transfer. Ad 11 and Ad 35, belonging to a subtype B group, use CD46 as their cellular receptors; accordingly, chimeric Ad5 whose fiber structure was substituted with that of the type 11 or 35 (Ad5/11 or Ad5/35) could infect human cells in a… CONTINUE READING

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