Adenovirus type 5 early region 1b gene product is required for efficient shutoff of host protein synthesis.

@article{Babiss1984AdenovirusT5,
  title={Adenovirus type 5 early region 1b gene product is required for efficient shutoff of host protein synthesis.},
  author={Lee E. Babiss and Harold S. Ginsberg},
  journal={Journal of virology},
  year={1984},
  volume={50 1},
  pages={202-12}
}
To determine the role adenovirus 5 early region 1b-encoded 21- and 55-kilodalton proteins play in adenovirus productive infection, mutants have been isolated which were engineered to contain small deletions or insertions at 5.8, 7.9, or 9.6 map units. By using an overlap recombination procedure involving H5dl314 (delta 3.7 to 4.6 map units) DNA cleaved at 2.6 map units with ClaI and the adenovirus 5 XhoI-C (0 to 15.5 map units) fragment containing the desired mutation, viral mutants were… CONTINUE READING

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