Adenovirus transduction induces expression of multiple chemokines and chemokine receptors in murine beta cells and pancreatic islets.

@article{Zhang2003AdenovirusTI,
  title={Adenovirus transduction induces expression of multiple chemokines and chemokine receptors in murine beta cells and pancreatic islets.},
  author={Nan Zhang and Bernd Schr{\"o}ppel and Dongmei Chen and Shuang Fu and Kelly L. Hudkins and Haojiang Zhang and Barbara M Murphy and R. Sung Reum Sung and Jonathan S. Bromberg},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2003},
  volume={3 10},
  pages={
          1230-41
        }
}
Adenoviral vectors are highly efficient for transferring genes to islets. However, the inflammatory and immune responses stimulated by adenovirus may be detrimental to islet survival. Given the role of chemokines and their receptors in inflammation, we analyzed their expression in isolated murine islets, in a murine beta cell line and in syngeneic islet grafts after adenovirus transduction (AdRSVLacZ). AdRSVLacZ transduction enhanced and induced the expression of a variety of chemokines… CONTINUE READING
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