Adenovirus targeting to HLA-A1/MAGE-A1-positive tumor cells by fusing a single-chain T-cell receptor with minor capsid protein IX

@article{Vrij2008AdenovirusTT,
  title={Adenovirus targeting to HLA-A1/MAGE-A1-positive tumor cells by fusing a single-chain T-cell receptor with minor capsid protein IX},
  author={J de Vrij and Taco G. Uil and Sanne K. van den Hengel and Steve J. Cramer and Danijela Koppers-Lalic and Marieke C. Verweij and Emmanuel J H J Wiertz and J. M. Vellinga and Ralph A. Willemsen and R C Hoeben},
  journal={Gene Therapy},
  year={2008},
  volume={15},
  pages={978-989}
}
Adenovirus vectors have great potential in cancer gene therapy. Targeting of cancer-testis (CT) antigens, which are specifically presented at the surface of tumor cells by human leukocyte antigen (HLA) class I molecules, is an attractive option. In this study, a single-chain T-cell receptor (scTCR) directed against the CT antigen melanoma-associated antigen (MAGE)-A1 in complex with the HLA class I molecule of haplotype HLA-A1 is fused with the C terminus of the adenovirus minor capsid protein… CONTINUE READING
12 Citations
54 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 54 references

A system for efficient generation of adenovirus protein IX-producing helper cell lines

  • J Vellinga, TG Uil, J de Vrij, MJWE Rabelink, L Lindholm, RC. Hoeben
  • J Gene Medicine
  • 2006

Similar Papers

Loading similar papers…