Adenovirus sequesters phosphorylated STAT1 at viral replication centers and inhibits STAT dephosphorylation.

@article{Sohn2011AdenovirusSP,
  title={Adenovirus sequesters phosphorylated STAT1 at viral replication centers and inhibits STAT dephosphorylation.},
  author={Sook-Young Sohn and Patrick Hearing},
  journal={Journal of virology},
  year={2011},
  volume={85 15},
  pages={7555-62}
}
Tyrosine phosphorylation and nuclear translocation of STAT1 indicate activation of interferon (IFN) signal transduction pathways. Here, we demonstrate that tyrosine-phosphorylated STAT1 is targeted by a unique mechanism in adenovirus (Ad)-infected cells. Ad is known to suppress IFN-inducible gene expression; however, we observed that Ad infection prolongs the tyrosine phosphorylation of STAT1 induced by alpha IFN in infected cells. To understand this paradoxical effect, we examined the… CONTINUE READING

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