Adenovirus receptors: implications for targeting of viral vectors.

@article{Arnberg2012AdenovirusRI,
  title={Adenovirus receptors: implications for targeting of viral vectors.},
  author={Niklas Arnberg},
  journal={Trends in pharmacological sciences},
  year={2012},
  volume={33 8},
  pages={442-8}
}
Cancer, cardiovascular disease, and infectious diseases are all global health threats. To combat these diseases with gene therapies, adenovirus-based vectors have been developed. Although certain clinical trials appear successful, there is an obvious need to improve the efficacy of most adenovirus-based vectors. For the most commonly used vector (based on type 5; Ad5), a main problem is its accumulation in the liver, which can be attributed to interactions with specific host factors. The… CONTINUE READING
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