Adenovirus-mediated wild-type p53 tumor suppressor gene therapy induces apoptosis and suppresses growth of human pancreatic cancer [seecomments].

@article{Bouvet1998AdenovirusmediatedWP,
  title={Adenovirus-mediated wild-type p53 tumor suppressor gene therapy induces apoptosis and suppresses growth of human pancreatic cancer [seecomments].},
  author={Michael Bouvet and Richard Bold and Jungeun Lee and Douglas B. Evans and James L Abbruzzese and Paul J. Chiao and David James McConkey and Joya Chandra and Sunil Chada and Bingliang Fang and J. L. A. Roth},
  journal={Annals of surgical oncology},
  year={1998},
  volume={5 8},
  pages={681-8}
}
BACKGROUND The p53 tumor suppressor gene is mutated in up to 70% of pancreatic adenocarcinomas. We determined the effect of reintroduction of the wild-type p53 gene on proliferation and apoptosis in human pancreatic cancer cells using an adenoviral vector containing the wild-type p53 tumor suppressor gene. METHODS Transduction efficiencies of six p53-mutant pancreatic cancer cell lines (AsPC-1, BxPC-3, Capan-1, CFPAC-1, MIA PaCa-2, and PANC-1) were determined using the reporter gene construct… CONTINUE READING
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