Adenovirus-mediated transforming growth factor-beta ameliorates ischemic necrosis of epigastric skin flaps in a rat model.

@article{Huemer2004AdenovirusmediatedTG,
  title={Adenovirus-mediated transforming growth factor-beta ameliorates ischemic necrosis of epigastric skin flaps in a rat model.},
  author={Georg Michael Huemer and Maziar Shafighi and Romed Meirer and Paul Debagge and H. Piza-katzer and Raffi Gurunluoglu},
  journal={The Journal of surgical research},
  year={2004},
  volume={121 1},
  pages={101-7}
}
BACKGROUND Gene therapy has been recently introduced as a novel approach to treat ischemic tissues by using the angiogenic potential of certain growth factors. We investigated the effect of adenovirus-mediated gene therapy with transforming growth factor-beta (TGF-beta) delivered into the subdermal space to treat ischemically challenged epigastric skin flaps in a rat model. MATERIAL AND METHODS A pilot study was conducted in a group of 5 animals pretreated with Ad-GFP and expression of green… CONTINUE READING

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