Adenovirus-mediated transfer of viral IL-10 gene inhibits murine collagen-induced arthritis.

  title={Adenovirus-mediated transfer of viral IL-10 gene inhibits murine collagen-induced arthritis.},
  author={Florence Apparailly and Claudie Verwaerde and Chantal Jacquet and Claude Auriault and Jacques Sany and Christian Jorgensen},
  journal={Journal of immunology},
  volume={160 11},
IL-10 is a potent anti-inflammatory cytokine that has received growing attention for its therapeutic potential. We examined the efficiency of adenoviral-mediated gene transfer of IL-10 on the incidence and severity of murine collagen-induced arthritis (CIA). Male DBA1 mice immunized with collagen II were treated by systemic administration of 10(9) plaque-forming units of replication-defective adenoviral vector expressing viral IL-10 (vIL-10) on day 30, when clinical symptoms of arthritis start… CONTINUE READING

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