Adenovirus-mediated transfer of the p53 family genes, p73 and p51/p63 induces cell cycle arrest and apoptosis in colorectal cancer cell lines: potential application to gene therapy of colorectal cancer

@article{Sasaki2001AdenovirusmediatedTO,
  title={Adenovirus-mediated transfer of the p53 family genes, p73 and p51/p63 induces cell cycle arrest and apoptosis in colorectal cancer cell lines: potential application to gene therapy of colorectal cancer},
  author={Yutaka Sasaki and Isao Morimoto and Seiko Ishida and Tetsuo Yamashita and Kohzoh Imai and Takashi Tokino},
  journal={Gene Therapy},
  year={2001},
  volume={8},
  pages={1401-1408}
}
p53 gene therapy is being tested clinically for the treatment of human cancer, however, some cancer models (in vivo and in vitro) are resistant to p53. To explore the potential use of two p53 homologues, p73 and p51/p63, in cancer gene therapy, we introduced p53, p73 and p51/p63 into colorectal cancer cell lines via adenoviral vectors, and compared their effects on cell growth. Among 10 cell lines tested, six cell lines displayed a similar response following transduction of p53, p73β or p51A… CONTINUE READING

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