Adenovirus-mediated thymidine kinase gene therapy and coxsackie adenovirus receptor expression in ovarian cancer cells.

@article{Kieback2008AdenovirusmediatedTK,
  title={Adenovirus-mediated thymidine kinase gene therapy and coxsackie adenovirus receptor expression in ovarian cancer cells.},
  author={Dirk G{\"u}nter Kieback},
  journal={Cancer genomics & proteomics},
  year={2008},
  volume={5 6},
  pages={311-8}
}
Coxsackie adenovirus receptor (CAR) expression is the main mechanism of adenovirus entry into target cells. It is unclear whether CAR expression itself is influenced by transduction with the adenovirus-Rous sarcoma virus-thymidine kinase (ADV-RSV-TK) gene therapy construct or by the subsequent intracellular accumulation of the TK gene product. Antibody… CONTINUE READING