Adenovirus-mediated sphingomyelin synthase 2 increases atherosclerotic lesions in ApoE KO mice

Abstract

Sphingomyelin synthase 2 (SMS2) contributes to de novo sphingomyelin (SM) biosynthesis. Its activity is related to SM levels in the plasma and the cell membrane. In this study, we investigated the possibility of a direct relationship between SMS and atherosclerosis. The Adenovirus containing SMS2 gene was given into 10-week ApoE KO C57BL/6J mice by femoral… (More)
DOI: 10.1186/1476-511X-10-7

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