Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinoma.

@article{Clayman1998AdenovirusmediatedPG,
  title={Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinoma.},
  author={Gary L Clayman and A El-naggar and Scott Michael Lippman and Ying C. Henderson and Mary Gena Frederick and James A. Merritt and Louis A. Zumstein and Terry Timmons and Ta Jen Liu and Lawrence Ginsberg and J. L. A. Roth and Waun Ki Hong and P. Bruso and Helmuth Goepfert},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={1998},
  volume={16 6},
  pages={2221-32}
}
PURPOSE Standard therapies of head and neck squamous cell carcinoma (HNSCC) often cause profound morbidity and have not significantly improved survival over the last 30 years. Preclinical studies showed that adenoviral vector delivery of the wild-type p53 gene reduced tumor growth in mouse xenograft models. Our purpose was to ascertain the safety and therapeutic potential of adenoviral (Ad)-p53 in advanced HNSCC. PATIENTS AND METHODS Patients with incurable recurrent local or regionally… CONTINUE READING
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