Adenovirus-mediated p53 gene therapy in osteosarcoma cell lines: sensitization to cisplatin and doxorubicin

@article{Ganjavi2006AdenovirusmediatedPG,
  title={Adenovirus-mediated p53 gene therapy in osteosarcoma cell lines: sensitization to cisplatin and doxorubicin},
  author={Hooman Ganjavi and Michael Stanley Gee and Aru Narendran and Nicole Parkinson and Malini Krishnamoorthy and Melvin H. Freedman and David Malkin},
  journal={Cancer Gene Therapy},
  year={2006},
  volume={13},
  pages={415-419}
}
The poor prognosis for patients with metastatic osteosarcoma (OS) indicates that new therapeutic options should be explored. Studies with adenoviral-mediated p53 gene transfer have been conducted in many cancer types including cervical, ovarian, prostatic and head and neck tumors. However, limited work has been carried out with pediatric cancers, including OS. Using three viral constructs containing cDNA for wild-type p53, mutant p53 (Cys135Ser) and lacZ, we studied the effect of adenoviral… CONTINUE READING

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