Adenovirus-mediated p53 gene therapy in osteosarcoma cell lines: sensitization to cisplatin and doxorubicin

  title={Adenovirus-mediated p53 gene therapy in osteosarcoma cell lines: sensitization to cisplatin and doxorubicin},
  author={Hooman Ganjavi and Michael Stanley Gee and Aru Narendran and Nicole Parkinson and Malini Krishnamoorthy and Melvin H. Freedman and David Malkin},
  journal={Cancer Gene Therapy},
The poor prognosis for patients with metastatic osteosarcoma (OS) indicates that new therapeutic options should be explored. Studies with adenoviral-mediated p53 gene transfer have been conducted in many cancer types including cervical, ovarian, prostatic and head and neck tumors. However, limited work has been carried out with pediatric cancers, including OS. Using three viral constructs containing cDNA for wild-type p53, mutant p53 (Cys135Ser) and lacZ, we studied the effect of adenoviral… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 26 extracted citations


Publications referenced by this paper.
Showing 1-9 of 9 references

High-level expression of the coxsackievirus and adenovirus receptor messenger RNA in osteosarcoma, Ewing’s sarcoma, and benign neurogenic tumors among musculoskeletal tumors

  • W Gu, A Ogose, H Kawashima, M Ito, T Ito, A Matsuba
  • Clin Cancer Res
  • 2004

Expression of the coxsackievirus and adenovirus receptor in musculoskeletal tumors and mesenchymal tissues: efficacy of adenoviral gene therapy for osteosarcoma

  • H Kawashima, A Ogose, T Yoshizawa, R Kuwano, T Hotta, H Hatano
  • Cancer Sci
  • 2003

Poplack DG (eds.), Principles and Practice of Pediatric Oncology

  • MP Link
  • 3rd edn. Lippincott-Raven: Philadelphia,
  • 1997

Similar Papers

Loading similar papers…