Adenovirus-mediated overexpression of dominant negative epidermal growth factor receptor-CD533 as a gene therapeutic approach radiosensitizes human carcinoma and malignant glioma cells.

@article{Lammering2001AdenovirusmediatedOO,
  title={Adenovirus-mediated overexpression of dominant negative epidermal growth factor receptor-CD533 as a gene therapeutic approach radiosensitizes human carcinoma and malignant glioma cells.},
  author={Guido M Lammering and P S Lin and Joseph N. Contessa and Janis L Hampton and Kristoffer Valerie and Rupert K A Schmidt-Ullrich},
  journal={International journal of radiation oncology, biology, physics},
  year={2001},
  volume={51 3},
  pages={775-84}
}
PURPOSE Epidermal growth factor receptor (EGFR) and other members of the ErbB family of receptor tyrosine kinases (RTK) mediate autocrine growth regulation in a wide spectrum of human tumor cells. We have previously demonstrated that in stably transfected mammary carcinoma cells a dominant negative (DN) mutant of EGFR, EGFR-CD533 is a potent inhibitor of EGFR and its cytoprotective signaling after exposure to ionizing radiation. In the present study, we further investigate the capacity of a… CONTINUE READING