Adenovirus-mediated over-expression of the cyclin/cyclin-dependent kinase inhibitor, p21 inhibits vascular smooth muscle cell proliferation and neointima formation in the rat carotid artery model of balloon angioplasty.

@article{Chang1995AdenovirusmediatedOO,
  title={Adenovirus-mediated over-expression of the cyclin/cyclin-dependent kinase inhibitor, p21 inhibits vascular smooth muscle cell proliferation and neointima formation in the rat carotid artery model of balloon angioplasty.},
  author={M. W. Chang and E. Barr and M. Lu and K. Barton and J. Leiden},
  journal={The Journal of clinical investigation},
  year={1995},
  volume={96 5},
  pages={
          2260-8
        }
}
  • M. W. Chang, E. Barr, +2 authors J. Leiden
  • Published 1995
  • Medicine
  • The Journal of clinical investigation
  • Vascular smooth muscle cell (VSMC) proliferation after arterial injury is important in the pathogenesis of a number of vascular proliferative disorders, including atherosclerosis and restenosis after balloon angioplasty. Thus, a better understanding of the molecular mechanisms underlying VSMC proliferation in response to arterial injury would have important therapeutic implications for patients with atherosclerotic vascular disease. The p21 protein is a negative regulator of mammalian cell… CONTINUE READING
    Expression of cyclin-dependent kinase inhibitors in vascular disease.
    • 269
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