Adenovirus-mediated in vivo gene transfer and expression in normal rat pancreas.

@article{Raper1996AdenovirusmediatedIV,
  title={Adenovirus-mediated in vivo gene transfer and expression in normal rat pancreas.},
  author={Steven E. Raper and Ronald P. DeMatteo},
  journal={Pancreas},
  year={1996},
  volume={12 4},
  pages={401-10}
}
Gene transfer into the pancreas would be useful for the treatment of a variety of disorders, including cystic fibrosis, diabetes, cancer, and immunomodulation of pancreatic allografts. A hypothesis that various cell populations in the pancreas could be targeted by recombinant adenoviruses was developed and tested. Gene transfer into the rat ductal epithelium, acinar cells, and islets of Langerhans was accomplished with a recombinant adenovirus containing bacterial beta-galactosidase by… CONTINUE READING

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