Adenovirus-mediated hypoxia-targeting cytosine deaminase gene therapy enhances radiotherapy in tumour xenografts

@article{Liu2007AdenovirusmediatedHC,
  title={Adenovirus-mediated hypoxia-targeting cytosine deaminase gene therapy enhances radiotherapy in tumour xenografts},
  author={Jian Liu and Hiroshi Harada and Masakazu Ogura and Tomonori Shibata and Masahiro Hiraoka},
  journal={British Journal of Cancer},
  year={2007},
  volume={96},
  pages={1871 - 1878}
}
Hypoxia is closely associated with the radioresistance of tumours; therefore, targeting hypoxic areas is very important for cancer therapy. The aim of this study is to establish such a targeting strategy by applying a bacterial cytosine deaminase (BCD)/5-fluorocytosine (5-FC) gene therapy system and to examine whether the strategy enhances the efficacy of radiotherapy in a tumour xenograft. The hypoxia-responsive promoter 5HREp, in which five copies of the hypoxia-response element (HRE) enhance… CONTINUE READING
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