Adenovirus-mediated gene transfer of the β2-adrenergic receptor to donor hearts enhances cardiac function

@article{Kypson1999AdenovirusmediatedGT,
  title={Adenovirus-mediated gene transfer of the β2-adrenergic receptor to donor hearts enhances cardiac function},
  author={Alan P. Kypson and Steven C. Hendrickson and Shahab A. Akhter and Katrina H Wilson and Patricia H. McDonald and Richard Lilly and Paul C. Dolber and Donald D. Glower and Robert J. Lefkowitz and Walter J Koch},
  journal={Gene Therapy},
  year={1999},
  volume={6},
  pages={1298-1304}
}
Gene transfer to modify donor heart function during transplantation has significant therapeutic implications. Recent studies by our laboratory in transgenic mice have shown that overexpression of β2-adrenergic receptors (β2-ARs) leads to significantly enhanced cardiac function. Thus, we investigated the functional consequences of adenovirus-mediated gene… CONTINUE READING