Adenovirus-mediated gene transfer of a secreted form of human macrophage scavenger receptor inhibits modified low-density lipoprotein degradation and foam-cell formation in macrophages.

@article{Laukkanen2000AdenovirusmediatedGT,
  title={Adenovirus-mediated gene transfer of a secreted form of human macrophage scavenger receptor inhibits modified low-density lipoprotein degradation and foam-cell formation in macrophages.},
  author={Johanna M Laukkanen and Pauliina Lehtolainen and Peter J Gough and David Greaves and Siamon Gordon and Seppo Yl{\"a}-Herttuala},
  journal={Circulation},
  year={2000},
  volume={101 10},
  pages={1091-6}
}
BACKGROUND Macrophage scavenger receptors (MSRs) play an important role in the pathogenesis of atherosclerosis. Therefore, local modulation of MSR activity could have a beneficial effect on atherogenesis. METHODS AND RESULTS We cloned a secreted "decoy" MSR (sMSR) that contains an extracellular portion of the human MSR type AI and constructed an adenoviral vector that directs high-level expression of sMSR in macrophages under the control of the human CD68 promoter. Expression of the sMSR… CONTINUE READING
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