Adenovirus-mediated expression of the HO-1 protein within MSCs decreased cytotoxicity and inhibited apoptosis induced by oxidative stresses

@article{HamediAsl2011AdenovirusmediatedEO,
  title={Adenovirus-mediated expression of the HO-1 protein within MSCs decreased cytotoxicity and inhibited apoptosis induced by oxidative stresses},
  author={Pejman Hamedi-Asl and Raheleh Halabian and Parisa Bahmani and Mahshid Mohammadipour and Mohammad Mohammadzadeh and Amaneh Mohammadi Roushandeh and Ali Jahanian-Najafabadi and Yoshikazu Kuwahara and Mehryar Habibi Roudkenar},
  journal={Cell Stress and Chaperones},
  year={2011},
  volume={17},
  pages={181-190}
}
The capacity of mesenchymal stem cells (MSCs) to survive and engraft in the target tissue may lead to promising therapeutic effects. However, the fact that the majority of MSCs die during the first few days following transplantation complicates cell therapy. Hence, it is necessary to strengthen the stem cells to withstand the rigors of the microenvironment to improve the efficacy of cell therapy. In this study, we manipulated MSCs to express a cytoprotective factor, heme oxygenase-1 (HO-1), to… CONTINUE READING
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