Adenovirus-mediated expression of interferon-alpha delays viral replication and reduces disease signs in swine challenged with porcine reproductive and respiratory syndrome virus.

@article{Brockmeier2009AdenovirusmediatedEO,
  title={Adenovirus-mediated expression of interferon-alpha delays viral replication and reduces disease signs in swine challenged with porcine reproductive and respiratory syndrome virus.},
  author={Susan L. Brockmeier and Kelly M. Lager and Marvin J. Grubman and D. Brough and Damodar Ettyreddy and Randy E Sacco and Phillip C Gauger and Crystal L. Loving and Ann C Vorwald and Marcus E. Kehrli and Howard D. Lehmkuhl},
  journal={Viral immunology},
  year={2009},
  volume={22 3},
  pages={173-80}
}
In this study, pigs were injected with a nonreplicating human adenovirus type 5 vector expressing porcine interferon-alpha (Ad5-pIFN-alpha) and then challenged with porcine reproductive and respiratory syndrome virus (PRRSV) to determine whether the presence of increased levels of IFN-alpha would decrease viral replication and/or disease. Groups of 10 pigs each were inoculated with Ad5-pIFN-alpha and not challenged, Ad5-pIFN-alpha and challenged with PRRSV 1 d later, or inoculated with a… CONTINUE READING