Adenovirus-mediated expression of human coagulation factor IX in the rhesus macaque is associated with dose-limiting toxicity.

@article{Lozier1999AdenovirusmediatedEO,
  title={Adenovirus-mediated expression of human coagulation factor IX in the rhesus macaque is associated with dose-limiting toxicity.},
  author={Jay N Lozier and Mark E. Metzger and Robert E Donahue and Richard A. Morgan},
  journal={Blood},
  year={1999},
  volume={94 12},
  pages={3968-75}
}
We used a first-generation adenovirus vector (AVC3FIX5) to assess whether human factor IX could be expressed and detected in the rhesus macaque, which we have shown does not make high-titer antibodies to human factor IX protein. Three animals received 1 x 10(10) to 1 x 10(11) plaque-forming units per kilogram by intravenous injection. Human factor IX was present within 24 hours of vector administration and peaked 4 days later at 4,000 ng/mL in the high-dose recipient, and lower levels were seen… CONTINUE READING

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