Adenovirus-mediated expression of antisense urokinase plasminogen activator receptor and antisense cathepsin B inhibits tumor growth, invasion, and angiogenesis in gliomas.

@article{Gondi2004AdenovirusmediatedEO,
  title={Adenovirus-mediated expression of antisense urokinase plasminogen activator receptor and antisense cathepsin B inhibits tumor growth, invasion, and angiogenesis in gliomas.},
  author={Christopher S. Gondi and S. Lakka and Niranjan Yanamandra and William C. Olivero and Dzung H. Dinh and Meena Gujrati and Ching H. Tung and Ralph Weissleder and J. Sunil Rao},
  journal={Cancer research},
  year={2004},
  volume={64 12},
  pages={4069-77}
}
We have shown previously that urokinase plasminogen activator receptor (uPAR) and cathepsin B are overexpressed during glioma progression, particularly at the leading edge of the tumor. In the present study, we simultaneously down-regulated uPAR and cathepsin B in SNB19 glioma cell monolayer or SNB19 spheroids using an adenoviral vector carrying antisense uPAR and antisense cathepsin B and a combination of these genes as determined by Western blot analysis. The Ad-uPAR-Cath B-infected cells… CONTINUE READING

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