Adenovirus-mediated expression of CYP2E1 produces liver toxicity in mice.

  title={Adenovirus-mediated expression of CYP2E1 produces liver toxicity in mice.},
  author={Jingxiang Bai and Arthur I. Cederbaum},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  volume={91 2},
Induction of cytochrome P450 2E1 by ethanol is believed to be one of the central pathways by which ethanol generates a state of oxidative stress and causes hepatotoxicity. In order to evaluate the biochemical and toxicological actions of CYP2E1 and its sensitization of hepatotoxin-induced injury, an adenovirus which can mediate overexpression of CYP2E1 was constructed. Injecting this virus into mice through the tail vein elevated CYP2E1 protein and activity twofold in the liver of the mice… CONTINUE READING


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