Adenovirus-mediated cytokine gene transfer at tissue sites. Overexpression of IL-6 induces lymphocytic hyperplasia in the lung.

@article{Xing1994AdenovirusmediatedCG,
  title={Adenovirus-mediated cytokine gene transfer at tissue sites. Overexpression of IL-6 induces lymphocytic hyperplasia in the lung.},
  author={Zhou Xing and Todd A. Braciak and Manel Jordana and Kenneth Croitoru and F L Graham and Jack Gauldie},
  journal={Journal of immunology},
  year={1994},
  volume={153 9},
  pages={4059-69}
}
The biologic function of cytokines may be best studied in the context of a defined tissue site. To establish a model for studying the function of IL-6 at local tissue sites, we targeted the IL-6 transgene into the bronchial epithelium in the lung of Sprague-Dawley rats by intratracheal administration of a recombinant human type 5 adenovirus with rat IL-6 cDNA incorporated into the E3 region of the viral genome. This approach led to a highly compartmentalized overexpression of the IL-6 transgene… CONTINUE READING
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