Adenovirus-mediated Wild-type p53 Expression Induces Apoptosis and Suppresses Tumorigenesis of Experimental Intracranial Human Malignant Glioma

@article{Cirielli1999AdenovirusmediatedWP,
  title={Adenovirus-mediated Wild-type p53 Expression Induces Apoptosis and Suppresses Tumorigenesis of Experimental Intracranial Human Malignant Glioma},
  author={Corrado Cirielli and Kyosuke Inyaku and Maurizio Colognesi Capogrossi and Xuan Yuan and Jeffery A. Williams},
  journal={Journal of Neuro-Oncology},
  year={1999},
  volume={43},
  pages={99-108}
}
Adenoviral-mediated gene transfer for the treatment of experimental intrinsic malignant brain neoplasms holds promise. The role, however, of intracellular, adenoviral-mediated p53 expression to inhibit growth of experimental human intracranial malignant gliomas remains largely unexplored. Using the AdCMV.p53 vector we measured the in vitro expression of p53 and the resultant effect upon U251 human malignant glioma cellular proliferation. We further measured the survival of nude mice after… CONTINUE READING
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Analysis of the p53 gene and its expression in human glioblastoma cells

  • EG Van Meir, T Kikuchi, +7 authors WK Cavenee
  • Cancer Res
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