Adenovirus-mediated CD40 ligand therapy induces tumor cell apoptosis and systemic immunity in the TRAMP-C2 mouse prostate cancer model.

Abstract

BACKGROUND The interaction between CD40 ligand (CD40L) and CD40 on antigen presenting cells is essential for the initiation of antigen-specific T-cell responses, whereas CD40L stimulation of CD40+ tumor cells can induce cellular apoptosis. We investigated the anti-tumor effects induced by CD40L gene transfer into the mouse prostate adenocarcinoma cell line… (More)

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Cite this paper

@article{Dzojic2006AdenovirusmediatedCL, title={Adenovirus-mediated CD40 ligand therapy induces tumor cell apoptosis and systemic immunity in the TRAMP-C2 mouse prostate cancer model.}, author={Helena Dzojic and A Loskog and Thomas H. T{\"{o}tterman and Magnus Essand}, journal={The Prostate}, year={2006}, volume={66 8}, pages={831-8} }