Adenovirus-mediated Bax overexpression for the induction of therapeutic apoptosis in prostate cancer.

@article{Li2001AdenovirusmediatedBO,
  title={Adenovirus-mediated Bax overexpression for the induction of therapeutic apoptosis in prostate cancer.},
  author={X X Li and Michela Marani and Jiaxin Yu and Bicheng Nan and Jennifer A. Roth and Susumu Kagawa and Bingliang Fang and Larry A. Denner and Marco Marcelli},
  journal={Cancer research},
  year={2001},
  volume={61 1},
  pages={186-91}
}
Using adenoviral technology, we overexpressed the proapoptotic molecules pro-caspase-3, pro-caspase-7, and Bax to induce therapeutic apoptosis of prostate cancer cell lines growing in vitro and in vivo. Because overexpressed pro-caspase-3 did not undergo autocatalytic activation in any of the five prostate cancer cell lines evaluated, this strategy was unable to engage any component of the apoptotic pathway. Overexpressed pro-caspase-7 was proteolytically cleaved in LNCaP and LnCaP-Bcl-2 cells… CONTINUE READING

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