Adenovirus interaction with distinct integrins mediates separate events in cell entry and gene delivery to hematopoietic cells.

Abstract

A major impediment to the effective use of adenovirus vectors for gene therapy is a lack of knowledge of how these vectors interact with diverse cell types in vivo. Adenovirus attachment to most human cell types is mediated by the fiber protein, which binds to an as yet unidentified cell receptor. In contrast to this, we report that adenovirus type 2 (Ad2… (More)

Topics

Cite this paper

@article{Huang1996AdenovirusIW, title={Adenovirus interaction with distinct integrins mediates separate events in cell entry and gene delivery to hematopoietic cells.}, author={S Huang and Tetsuji Kamata and Yasutsugu Takada and Zaverio M Ruggeri and Glen R. Nemerow}, journal={Journal of virology}, year={1996}, volume={70 7}, pages={4502-8} }