Adenovirus infection stimulates the Raf/MAPK signaling pathway and induces interleukin-8 expression.

  title={Adenovirus infection stimulates the Raf/MAPK signaling pathway and induces interleukin-8 expression.},
  author={Joseph T. Bruder and Imi Kovesdi},
  journal={Journal of virology},
  volume={71 1},
Previous studies have shown that airway administration of adenovirus or adenovirus vectors results in a dose-dependent inflammatory response which limits the duration of transgene expression. We explored the possibility that adenovirus infection triggers signal transduction pathways that induce the synthesis of cytokines and thus contribute to the early inflammatory response. Since stimulation of the Raf/mitogen-activated protein kinase (MAPK) pathway activates transcription factors that… CONTINUE READING


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