Adenovirus hexon T-cell epitope is recognized by most adults and is restricted by HLA DP4, the most common class II allele

@article{Tang2004AdenovirusHT,
  title={Adenovirus hexon T-cell epitope is recognized by most adults and is restricted by HLA DP4, the most common class II allele},
  author={James Jianming Tang and Melanie Olive and Kelly Champagne and Neal Flomenberg and Laurence Eisenlohr and Susan H. Hsu and Phyllis R Flomenberg},
  journal={Gene Therapy},
  year={2004},
  volume={11},
  pages={1408-1415}
}
The immunogenicity of adenovirus (Ad) vectors is enhanced by virus-specific memory immune responses present in most individuals as a result of past exposure to these ubiquitous pathogens. We previously identified the first human T-cell epitope from the major capsid protein hexon, H910-924, and found that it is highly conserved among different Ad serotypes. Memory/effector T-cell responses to H910-924 were detected in 14 of 18 (78%) healthy adults by an interferon-γ ELISPOT assay. Hexon peptide… CONTINUE READING

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CD4(+) T cell recognition of MHC class II-restricted epitopes from NY-ESO-1 presented by a prevalent HLA DP4 allele: association with NY-ESO-1 antibody production

G Zeng
Proc Natl Acad Sci USA • 2001

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