Adenovirus genes that modulate the sensitivity of virus-infected cells to lysis by TNF.

@article{Wold1993AdenovirusGT,
  title={Adenovirus genes that modulate the sensitivity of virus-infected cells to lysis by TNF.},
  author={William S. M. Wold},
  journal={Journal of cellular biochemistry},
  year={1993},
  volume={53 4},
  pages={329-35}
}
TNF is a key inflammatory cytokine with antiviral properties. Human adenoviruses encode several intracellular proteins that mediate the effects of TNF. Expression of the adenovirus immediate early E1A proteins induces viral genes and a host of cellular genes, drives G0 cells into S-phase, and induces apoptosis and susceptibility to TNF-induced apoptosis. The adenovirus E1B-19K protein inhibits both E1A- and TNF-induced apoptosis. The E3-14.7K protein and the E3-10.4K/14.5K complex of proteins… CONTINUE READING

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