Adenovirus expressing dual c-Met-specific shRNA exhibits potent antitumor effect through autophagic cell death accompanied by senescence-like phenotypes in glioblastoma cells

Abstract

c-Met, a cognate receptor tyrosine kinase of hepatocyte growth factor, is overexpressed and/or mutated in number of tumors. Therefore, abrogation of c-Met signaling may serve as potential therapeutic targets. In this study, we generated Ads expressing single shRNA specific to c-Met (shMet) (dl/shMet4 and dl/shMet5) or dual shRNAs specific to c-Met (dl… (More)

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@inproceedings{Lee2015AdenovirusED, title={Adenovirus expressing dual c-Met-specific shRNA exhibits potent antitumor effect through autophagic cell death accompanied by senescence-like phenotypes in glioblastoma cells}, author={Jung-Sun Lee and Eonju Oh and Ji Young Janice Yoo and Kyeong Sook Choi and Mi Jin Yoon and Chae-Ok Yun}, booktitle={Oncotarget}, year={2015} }