Adenovirus evasion of interferon-mediated innate immunity by direct antagonism of a cellular histone posttranslational modification.

@article{Fonseca2012AdenovirusEO,
  title={Adenovirus evasion of interferon-mediated innate immunity by direct antagonism of a cellular histone posttranslational modification.},
  author={Gregory Fonseca and Gobi Thillainadesan and Ahmed F. Yousef and Jailal N Ablack and Karen Louise Mossman and Joseph Torchia and Joe S. Mymryk},
  journal={Cell host & microbe},
  year={2012},
  volume={11 6},
  pages={597-606}
}
Overcoming the cellular type I interferon (IFN) host defense response is critical for a virus to ensure successful infection. Investigating the effects of human adenovirus (HAdV) infection on global cellular histone posttranslational modification (hPTM), we discovered that virus infection-induced activation of IFN signaling triggers a global increase in the monoubiquitination of histone 2B (H2B) at lysine 120, which is a mark for transcriptionally active chromatin. This hPTM, catalyzed by the… CONTINUE READING

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