Adenovirus encoding human platelet-derived growth factor-B delivered in collagen exhibits safety, biodistribution, and immunogenicity profiles favorable for clinical use.

@article{Gu2004AdenovirusEH,
  title={Adenovirus encoding human platelet-derived growth factor-B delivered in collagen exhibits safety, biodistribution, and immunogenicity profiles favorable for clinical use.},
  author={D. L. Gu and Thanh Nguyen and Ana Maria Gonzalez and Marie A. Printz and G F Pierce and Barbara A Sosnowski and Michael L. Phillips and Lois A. Chandler},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2004},
  volume={9 5},
  pages={699-711}
}
We have developed a therapeutic approach to wound repair involving immobilization of gene transfer vectors within biocompatible matrices (gene-activated matrix, or GAM). The matrix also serves as a scaffold for cellular in-growth and subsequent gene uptake and expression. An adenoviral vector encoding human platelet-derived growth factor-B delivered in collagen (AdPDGF-B/GAM) has demonstrated efficacy in models of wound repair. The safety, biodistribution, and immunogenicity profiles of AdPDGF… CONTINUE READING

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