Adenovirus detection by the cGAS/STING/TBK1 DNA sensing cascade.

  title={Adenovirus detection by the cGAS/STING/TBK1 DNA sensing cascade.},
  author={E W -F Lam and Saskia C Stein and Erik Falck-Pedersen},
  journal={Journal of virology},
  volume={88 2},
Adenovirus (Ad) infection triggers a cell-specific antiviral response following exposure of viral DNA to the intracellular compartment. A variety of DNA sensors (DAI, AIM2, DDx41, RNA polymerase [Pol] III, and IFI16 [p204]) have been identified in recent years; however, the DNA sensor involved in detection of adenovirus has not been established. Cyclic GMP-AMP synthase (cGAS), a DNA sensor that produces a cyclic guanine-adenine dinucleotide (cGAMP) inducer of STING, has been examined to… CONTINUE READING
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