Adenovirus detection by the cGAS/STING/TBK1 DNA sensing cascade.

@article{Lam2014AdenovirusDB,
  title={Adenovirus detection by the cGAS/STING/TBK1 DNA sensing cascade.},
  author={E W -F Lam and Saskia C Stein and Erik Falck-Pedersen},
  journal={Journal of virology},
  year={2014},
  volume={88 2},
  pages={974-81}
}
Adenovirus (Ad) infection triggers a cell-specific antiviral response following exposure of viral DNA to the intracellular compartment. A variety of DNA sensors (DAI, AIM2, DDx41, RNA polymerase [Pol] III, and IFI16 [p204]) have been identified in recent years; however, the DNA sensor involved in detection of adenovirus has not been established. Cyclic GMP-AMP synthase (cGAS), a DNA sensor that produces a cyclic guanine-adenine dinucleotide (cGAMP) inducer of STING, has been examined to… CONTINUE READING
54 Citations
49 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 54 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 49 references

Similar Papers

Loading similar papers…