Adenovirus complexed with polyethylene glycol and cationic lipid is shielded from neutralizing antibodies in vitro

@article{Chilln1998AdenovirusCW,
  title={Adenovirus complexed with polyethylene glycol and cationic lipid is shielded from neutralizing antibodies in vitro},
  author={M. Chill{\'o}n and J. Lee and A. Fasbender and M. Welsh},
  journal={Gene Therapy},
  year={1998},
  volume={5},
  pages={995-1002}
}
Development of neutralizing antibodies is an important hindrance that limits repeated administration of adenoviral vectors for gene transfer. One way to avoid this problem would be to coat the virus with a substance that could shield it from antibodies. To develop such a system, we coated negatively-charged adenovirus with the cationic lipid GL-67 and included polyethylene glycol (PEG) in the complex as dioleoylphosphatidylethanolamine-PEG (DOPE-PEG). This complex enhanced gene transfer to… Expand
118 Citations
Utility of PEGylated recombinant adeno-associated viruses for gene transfer.
  • 54
Receptor-independent augmentation of adenovirus-mediated gene transfer with chitosan in vitro.
  • 33
Enhancing the therapeutic efficacy of adenovirus in combination with biomaterials.
  • 50
Current advances in developing cationic lipid-based nanoparticles as a vehicle for improving adenoviral gene delivery
  • 5
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 36 REFERENCES
Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy.
  • 1,645
  • PDF
The role of the adenovirus protease on virus entry into cells.
  • 326
  • PDF
Neutralization of adenoviruses: kinetics, stoichiometry, and mechanisms.
  • 143
  • PDF
...
1
2
3
4
...