Adenovirus complexed with polyethylene glycol and cationic lipid is shielded from neutralizing antibodies in vitro

@article{Chilln1998AdenovirusCW,
  title={Adenovirus complexed with polyethylene glycol and cationic lipid is shielded from neutralizing antibodies in vitro},
  author={Miguel Chill{\'o}n and Jh Lee and Andreas Fasbender and MJ Welsh},
  journal={Gene Therapy},
  year={1998},
  volume={5},
  pages={995-1002}
}
Development of neutralizing antibodies is an important hindrance that limits repeated administration of adenoviral vectors for gene transfer. One way to avoid this problem would be to coat the virus with a substance that could shield it from antibodies. To develop such a system, we coated negatively-charged adenovirus with the cationic lipid GL-67 and included polyethylene glycol (PEG) in the complex as dioleoylphosphatidylethanolamine-PEG (DOPE-PEG). This complex enhanced gene transfer to… CONTINUE READING

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