Adenovirus VAI RNA antagonizes the antiviral action of interferon by preventing activation of the interferon-induced eIF-2 alpha kinase.

@article{Kitajewski1986AdenovirusVR,
  title={Adenovirus VAI RNA antagonizes the antiviral action of interferon by preventing activation of the interferon-induced eIF-2 alpha kinase.},
  author={Jan Kitajewski and Robert J Schneider and Brian Safer and S M Munemitsu and Charles E. Samuel and B Thimmappaya and Thomas E. Shenk},
  journal={Cell},
  year={1986},
  volume={45 2},
  pages={195-200}
}
The VAI RNA of adenovirus is a small, RNA polymerase III-transcribed species required for efficient translation of host cell and viral mRNAs late after infection. The growth of a viral mutant that is unable to produce the RNA is inhibited by interferon, while wild-type virus is not affected. VAI RNA prevents activation of the interferon-induced P1/eIF-2 alpha kinase. This inhibition can be reproduced in extracts of interferon-treated cells where purified VAI RNA prevents activation of latent… CONTINUE READING

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