Adenovirus Type 5 Induces Vitamin A–Metabolizing Enzymes in Dendritic Cells and Enhances Priming of Gut Homing CD8 T Cells

@inproceedings{Ganguly2011AdenovirusT5,
  title={Adenovirus Type 5 Induces Vitamin A–Metabolizing Enzymes in Dendritic Cells and Enhances Priming of Gut Homing CD8 T Cells},
  author={Sumita Ganguly and Santhakumar Manicassamy and Rama Rao Amara},
  booktitle={Mucosal Immunology},
  year={2011}
}
Protective immunity at the gut-associated mucosal tissue is induced primarily by oral/rectal immunization owing to the need for targeting antigen to the gut-resident dendritic cells (DCs). In this study we show that an adenovirus type 5 (Ad5)-based human immunodeficiency virus type 1 vaccine can prime a durable antigen-specific CD8 T-cell response in the gut following intramuscular (IM) immunization in mice. The ability of Ad5 to prime gut-homing CD8 T cells in vivo was associated with Ad5… CONTINUE READING

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