Adenovirus-Specific Immunity Following Immunization with an Ad5 HIV-1 Vaccine Candidate in Humans

  title={Adenovirus-Specific Immunity Following Immunization with an Ad5 HIV-1 Vaccine Candidate in Humans},
  author={Kara L. O’Brien and Jinyan Liu and Sharon L. King and Yiming Sun and Joern E Schmitz and Michelle A. Lifton and Natalie A. Hutnick and Michael R Betts and Sheri A. Dubey and Jaap Goudsmit and John Shiver and Michael N. Robertson and Danilo R. Casimiro and Dan H Barouch},
  booktitle={Nature Medicine},
The immunologic basis for the potential enhanced HIV-1 acquisition in adenovirus serotype 5 (Ad5)-seropositive individuals who received the Merck recombinant Ad5 HIV-1 vaccine in the STEP study remains unclear. Here we show that baseline Ad5-specific neutralizing antibodies are not correlated with Ad5-specific T lymphocyte responses and that Ad5-seropositive subjects do not develop higher vector-specific cellular immune responses as compared with Ad5-seronegative subjects after vaccination… CONTINUE READING

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