Adenovirus-Mediated Overexpression of Septin 2 Attenuates α-Smooth Muscle Actin Expression and Adventitial Myofibroblast Migration Induced by Angiotensin II.

@article{Guo2016AdenovirusMediatedOO,
  title={Adenovirus-Mediated Overexpression of Septin 2 Attenuates α-Smooth Muscle Actin Expression and Adventitial Myofibroblast Migration Induced by Angiotensin II.},
  author={Shu-jie Guo and Peng Zhang and Ling-Yun Wu and Guan-nan Zhang and Wen-dong Chen and Ping-jin Gao},
  journal={Journal of vascular research},
  year={2016},
  volume={53 5-6},
  pages={309-316}
}
Phenotypic transformation from adventitial fibroblasts (AFs) to myofibroblasts (MFs) is critical for vascular remodeling. Septin 2 was found to be downregulated during the differentiation of AFs to MFs induced by angiotensin II (Ang II); however, the role of septin 2 in this process is still unknown. In this study, we investigate whether septin 2 contributes to the adventitial MF phenotypic modulation caused by Ang II. The decreased level of septin 2 and the increased expression of α-smooth… CONTINUE READING

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