Adenovirus-Mediated Bcl-Xl Gene Therapy Combined with Pronase Treatment Protects the Small Intestine from Radiation-Induced Enteritis in Mouse Model

@article{Koyama2014AdenovirusMediatedBG,
  title={Adenovirus-Mediated Bcl-Xl Gene Therapy Combined with Pronase Treatment Protects the Small Intestine from Radiation-Induced Enteritis in Mouse Model},
  author={F. Koyama and Kazuaki Uchimoto and H. Fujii and H. Hamada and K. Ohashi and T. Nomi and T. Nakagawa and S. Nakamura and T. Ueda and Y. Nakajima},
  journal={Journal of Genetic Syndromes & Gene Therapy},
  year={2014},
  volume={5},
  pages={1-8}
}
  • F. Koyama, Kazuaki Uchimoto, +7 authors Y. Nakajima
  • Published 2014
  • Biology
  • Journal of Genetic Syndromes & Gene Therapy
  • Intestinal injury is a major side effect of radiation treatment for many malignancies. The present study investigated whether transducing Bcl-xL, a potent anti-apoptotic gene, into intestinal epithelial cells would exert protective effects against radiation-induced acute injuries. Methods: Adenoviral vectors containing the human Bcl-xL gene (AxCABclxL) or β-galactosidase gene (AxCAlacZ) driven by the CAG promoter were generated. To increase transduction efficiency into the mucosal epithelium… CONTINUE READING
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