Adenovirus E4ORF1-induced MYC activation promotes host cell anabolic glucose metabolism and virus replication.

@article{Thai2014AdenovirusEM,
  title={Adenovirus E4ORF1-induced MYC activation promotes host cell anabolic glucose metabolism and virus replication.},
  author={Minh Duc Thai and Nicholas A Graham and Daniel Braas and Michael T Nehil and Evangelia Komisopoulou and Siavash K Kurdistani and Frank McCormick and Thomas G Graeber and Heather R Christofk},
  journal={Cell metabolism},
  year={2014},
  volume={19 4},
  pages={
          694-701
        }
}
Virus infections trigger metabolic changes in host cells that support the bioenergetic and biosynthetic demands of viral replication. Although recent studies have characterized virus-induced changes in host cell metabolism (Munger et al., 2008; Terry et al., 2012), the molecular mechanisms by which viruses reprogram cellular metabolism have remained elusive. Here, we show that the gene product of adenovirus E4ORF1 is necessary for adenovirus-induced upregulation of host cell glucose metabolism… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 48 CITATIONS

Viral activation of cellular metabolism.

VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Virus-host interactions under hypoxia.

  • Microbes and infection
  • 2017
VIEW 4 EXCERPTS
HIGHLY INFLUENCED

Role of adenoviruses in obesity.

  • Reviews in medical virology
  • 2015
VIEW 3 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 18 REFERENCES

Similar Papers

Loading similar papers…