Adenovirus E1A proteins interact with the cellular YY1 transcription factor.

  title={Adenovirus E1A proteins interact with the cellular YY1 transcription factor.},
  author={Brian A. Lewis and Gregory E Tullis and Edward Seto and Nobuo Horikoshi and Ralf-Philipp Weinmann and Thomas E. Shenk},
  journal={Journal of virology},
  volume={69 3},
The adenovirus 12S and 13S E1A proteins have been shown to relieve repression mediated by the cellular transcription factor YY1. The 13S E1A protein not only relieves repression but also activates transcription through YY1 binding sites. In this study, using a variety of in vivo and in vitro assays, we demonstrate that both E1A proteins can bind to YY1, although the 13S E1A protein binds more efficiently than the 12S E1A protein. Two domains on the E1A proteins interact with YY1: an amino… CONTINUE READING

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