Adenovirus E1A proteins are closely associated with chromatin in productively infected and transformed cells.

@article{Green2008AdenovirusEP,
  title={Adenovirus E1A proteins are closely associated with chromatin in productively infected and transformed cells.},
  author={Maurice Green and N. Panesar and P. Loewenstein},
  journal={Virology},
  year={2008},
  volume={371 1},
  pages={
          1-7
        }
}
The adenovirus E1A 243R oncoprotein encodes a potent transcription-repression function within the N-terminal 80 amino acids. Our proposed model of E1A repression predicts that E1A interacts with important cellular proteins on chromatin. Consistent with this idea, we report here that E1A proteins from in vivo formaldehyde cross-linked 293 cells are closely associated with chromatin even after several stringent purification steps including double isopycnic CsCl density gradient centrifugation and… Expand

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