Adenovirus E1A oncoprotein liberates c-Myc activity to promote cell proliferation through abating Bin1 expression via an Rb/E2F1-dependent mechanism.

@article{Kinney2008AdenovirusEO,
  title={Adenovirus E1A oncoprotein liberates c-Myc activity to promote cell proliferation through abating Bin1 expression via an Rb/E2F1-dependent mechanism.},
  author={Erica L Kinney and Satoshi Tanida and Amelie A Rodrigue and Joanna K Johnson and Van S. Tompkins and Daitoku Sakamuro},
  journal={Journal of cellular physiology},
  year={2008},
  volume={216 3},
  pages={621-31}
}
Adenovirus E1A oncogene transforms primary rodent fibroblasts in cooperation with activated Ras. Conversely, the c-Myc oncoprotein-binding tumor suppressor, Bin1, inhibits Ras/E1A-mediated cell transformation. Since E1A does not directly bind to and inhibit Bin1, the primary mechanism by which E1A counteracts Bin1 to liberate oncogenic c-Myc activity is poorly understood. Here we show that wild-type E1A, but not an Rb binding-defective E1A mutant, suppresses endogenous Bin1 expression in… CONTINUE READING
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