Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product.

@article{Chellappan1992AdenovirusES,
  title={Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product.},
  author={Srikumar Chellappan and Virginia B. Kraus and B Kroger and Karl Munger and Peter M Howley and Warner Phelps and J. R. Nevins},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 10},
  pages={4549-53}
}
The adenovirus E1A gene product, the simian virus 40 large tumor antigen, and the human papillomavirus E7 protein share a short amino acid sequence that constitutes a domain required for the transforming activity of these proteins. These sequences are also required for these proteins to bind to the retinoblastoma gene product (pRb). Recent experiments have shown that E1A can dissociate complexes containing the transcription factor E2F bound to pRb, dependent on this conserved sequence element… CONTINUE READING

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